Risultati aggiornati dello studio EORTC 1325-MG/KEYNOTE-054 L’estensione del follow-up conferma l’effetto positivo di pembrolizumab sulla sopravvivenza senza ricorrenza di malattia nel melanoma ad alto rischio di […]
Postoperative Critical Events Associated With Obstructive Sleep Apnea: Results From the Society of Anesthesia and Sleep Medicine Obstructive Sleep Apnea Registry Abstract BACKGROUND: obstructive sleep apnea (OSA) patients are at increased risk for pulmonary and cardiovascular complications; perioperative mortality risk is […]
Prolonged versus intermittent β-lactam antibiotics intravenous infusion strategy in sepsis or septic shock patients: a systematic review with meta-analysis and trial sequential analysis of randomized trials Abstract BACKGROUND: the prolonged β-lactam infusion strategy has emerged as the standard treatment for sepsis or septic shock despite its […]
Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes In direzione opposta alla presenza di uno “storm citochinico” nei pazienti con COVID-19 vanno i risultati di una revisione della […]
Dexmedetomidine: another arrow in the quiver to fight COVID-19 in intensive care units Commento L’entità ed il ruolo della risposta citochinica pro-infiammatoria nella patogenesi del COVID-19 sono ancora oggetto di ricerche e di […]
5-HT3 receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials. Objective: perioperative shivering (POS) is a common complication in patients undergoing spinal anaesthesia. The present study investigated the efficacy of 5-HT3 receptor […]
Pembrolizumab più axitinib verso sunitinib per il carcinoma renale avanzato Il carcinoma renale è caratterizzato dalla sensibilità agli approcci terapeutici sia di tipo immunoterapico sia ad azione antiangiogenica e dalla […]
Comparison of incidence of anaphylaxis between sugammadex and neostigmine: a retrospective multicentre observational study BACKGROUND: although cases of anaphylaxis caused by sugammadex have been reported, its incidence remains uncertain. Conversely, no studies have evaluated […]
Use of sugammadex in patients with neuromuscular disorders: a systematic review of case reports BACKGROUND: sugammadex is a modified gamma-cyclodextrin that acts by selectively encapsulating free amino-steroidal neuromuscular relaxants. Several case reports have been […]
Airway management in anesthesia for thoracic surgery: a “real life” observational study Abstract BACKGROUND: one-lung ventilation (OLV) in thoracic anesthesia is required to provide good surgical exposure. OLV is commonly achieved through […]
Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in Healthy Volunteers: A Nonblinded Randomized Crossover Study Abstract BACKGROUND: dexmedetomidine is a sedative promoted as having minimal impact on ventilatory drive or upper airway muscle activity. However, […]
Saline versus Lactated Ringer’s Solution: The Saline or Lactated Ringer’s (SOLAR) Trial Abstract WHAT WE ALREADY KNOW ABOUT THIS TOPIC: infusion of large volumes of saline causes hyperchloremic metabolic acidosisA recent Cochrane review […]